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生物科技COVID-19 (BNT162b2) 疫苗接种和小 Varicella Zoster重新激活:一个全面的横截面研究

Shir Azrielant¹, Yair Levin¹, Alon Peled²

¹Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Acta dermato-venereologica

|February 13, 2024

概括

接种COVID-19疫苗并没有增加疹疹 (HZ) 住院或并发症的风险. 一项研究发现,瑞-生物科技疫苗与接种疫苗的人群中HZ严重程度之间没有显著的关联.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
流行病学流行病学

背景情况:

带状疹 (HZ) 是由疹-带状疹病毒的重新激活引起的.
最近的观察表明,COVID-19疫苗接种和HZ之间的潜在联系.
调查这种关联对公共卫生至关重要.

研究的目的:

为了检查COVID-19疫苗接种和HZ严重程度之间的关联.
为了比较接种疫苗和未接种疫苗的HZ患者的住院率和并发症.

主要方法:

一项单中心的横截面研究分析了2017-2021年间的HZ患者.
一个回顾性队列比较了接种疫苗和未接种疫苗的HZ患者在Pfizer-BioNTech COVID-19疫苗后.
对照组包括细胞炎和骨折诊断.

主要成果:

初步的多变量分析表明,接种疫苗的人的入院率更高 (OR2.75,p=0.01).
通过匹配和分层进行混控制使这些初步发现无效.
在住院时间或并发症方面没有发现显著差异.

结论:

接种COVID-19疫苗与与HZ相关的入院风险增加无关.
在接种疫苗的人群中没有观察到HZ并发症的风险增加.
这项研究提供了证据证明COVID-19疫苗接种和HZ严重程度之间的联系.

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