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人类CST复合物通过抑制p21来限制过度的PrimPol抑制UV诱导的复制应激

Pau Biak Sang1,2, Rishi K Jaiswal1,3, Xinxing Lyu1

  • 1Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.

Nucleic acids research
|February 13, 2024
PubMed
概括

DNA复制压力阻碍了DNA合成. 研究人员发现,耗尽CST蛋白质通过调节p21相互作用,通过PrimPol (一种专门的聚合酶) 增强复制重启.

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