免疫调节疗法在经历辅助怀孕的复发性植入失败妇女的使用:一个多中心队列研究
Mohammed Khairy1, Hoda Harb2, Abey Eapen3
1CARE Fertility Birmingham, Birmingham, Edgbaston, UK.
American journal of reproductive immunology (New York, N.Y. : 1989)
|February 13, 2024
概括
免疫调节疗法,包括皮质类固醇和肝素,在接受辅助生殖治疗 (ART) 的女性中改善了复发性植入失败 (RIF) 的活产率. 需要进一步的研究来证实这些发现,并标准化免疫疾病查.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 复发性植入失败 (RIF) 是ART的一个重大挑战.
- 免疫调节疗法对RIF显示出不同的结果.
- 确定RIF的有效治疗方法对于提高ART成功率至关重要.
研究的目的:
- 评估免疫调节疗法对患有RIF的妇女活产率 (LBR) 的影响.
- 评估免疫调节剂作为标准ART的辅助剂的疗效.
主要方法:
- 对接受RIF治疗的妇女进行回顾性队列研究.
- 在接受免疫调节剂和仅接受标准ART的妇女之间比较LBR,临床怀孕率 (CPR),累积活产率 (CLBR) 和流产率.
- 免疫调节包括皮质类固醇,低分子量肝素 (LMWH) 和静脉内脂类 (IVIL) 输液.
主要成果:
- 与单独使用标准ART相比,免疫调节疗法与较高的LBR (20.9%与15.8%) 有关.
- 多变量分析证实免疫调节是活产的独立预测因子 (aOR 1.33).
- 存活率分析表明,治疗组的累积活产率显著更高 (aHR 1.78).
结论:
- 免疫调节疗法在免疫学测试后对RIF妇女显示了潜在的益处.
- 需要高质量的随机对照试验 (RCT) 来确认免疫调节在RIF中的作用.
- 迫切需要对影响植入的免疫疾病进行标准化查测试.
关键词:
艺术 艺术 艺术 艺术在这个过程中,IVF IVF.有助于生殖的治疗治疗.这是一种皮质类固醇.免疫治疗 免疫治疗在脂质内部的脂肪.低分子量肝素是什么普雷迪尼索隆 (prednisolone) 是一种药物.经常发生的植入失败.更多相关视频
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