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消极的童年经历,低自尊和突出的刺激反应在饮食障碍中的表现
Sarah Lagan1, Megan E Shott2, Guido K W Frank2,3
1University of California San Diego, School of Medicine, San Diego, California, USA.
概括
儿童不良经历 (ACE) 通过改变大脑对刺激的反应,影响饮食障碍 (ED). 低自尊调解了这些影响,这表明ACE对ED神经生物学和治疗至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 儿童不良经历 (ACE) 在患有饮食障碍 (ED) 的人群中很常见.
- 在ACE和ED之间的神经生物学相互作用仍然不太清楚.
- 了解这种相互作用对于开发有效的治疗方法至关重要.
研究的目的:
- 研究将ACE和ED联系在一起的神经生物学机制.
- 检查自尊在调解ACE和ED行为之间的关系中的作用.
- 探索ACE如何影响ED患者在味道调节任务期间的大脑反应.
主要方法:
- 参与者包括有神经性厌食症 (AN),神经性嗜食症 (BN) 和健康对照的女性.
- 评估了ACE,ED行为和自尊.
- 在味道调节任务中,用功能神经影像测量了大脑活动.
- 用调解分析来测试拟议的关系.
主要成果:
- 患有ED的个人报告了较高的ACE分数,与BMI相关,驱使瘦身和身体不满.
- 低自尊调解了ACE和身体不满,瘦身的驱动力和嗜食症严重程度之间的关联.
- ACE评分与大脑区域对意外刺激的神经反应有负相关性,包括黑质体,前带带状,额叶和岛屿皮层和腹状条纹体.
- 在患有ED的个体中,ACE得分与前带带皮和腹条纹体中对意想不到的刺激的脑反应升高有关.
结论:
- ACE似乎会减弱对突出刺激的反应,这可能表明EDs的奖励处理发生了变化.
- 低自尊是一个关键的调解者,将ACE与ED精神病理联系起来.
- 在ED的生物研究和临床干预中,应该考虑ACEs.
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