从基于多卢特格拉维尔的治疗转换为比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺
Chloe Orkin1, Andrea Antinori2, Jürgen K Rockstroh3
1Queen Mary University of London, London, UK.
AIDS (London, England)
|February 13, 2024
概括
切换为比克特格拉维尔/emtricitabine/tenofovir alafenamide (B/F/TAF) 维持了HIV-1病毒抑制和CD4+细胞计数. 这种艾滋病毒治疗是长期安全有效的,副作用最小.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床药理学 临床药理学
背景情况:
- 基于多卢特格拉维尔 (DTG) 的疗法是标准的第一线HIV-1治疗.
- 评估切换到比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (B/F/TAF) 的长期疗效和安全性对于患者管理至关重要.
研究的目的:
- 为了评估从基于DTG的疗法转换到B/F/TAF的疗法在96周内的疗效和安全性.
- 为了评估病毒抑制,CD4+细胞计数变化和治疗出现的耐药性.
主要方法:
- 分析了3期随机试验 (1489和1490研究).
- 进行了对B/F/TAF的96周开放式延期 (OLE) 的综合分析.
- 转换后评估了病毒抑制,CD4+细胞计数,安全性和耐受性.
主要成果:
- 在OLE 96.6周观察到高病毒抑制 (99.1-99.5%) 和维持的CD4+细胞计数.
- 没有检测到对B/F/TAF的治疗出现的耐药性.
- 不良事件通常是轻微的,腹,体重增加和头痛最常见;没有发生严重的不良事件或管病变.
结论:
- 从基于DTG的疗法转换为B/F/TAF,对于长期的HIV-1管理是安全有效的.
- 该疗法表现出持续的病毒抑制和有利的安全性.
- 这一策略为一线艾滋病毒治疗的患者提供了可行的选择.
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