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Updated: May 10, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
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梅索他林抗原密度影响抗梅索他林化学抗原受体T细胞细胞毒性

Gerard J Chu1, Charles G Bailey2, Rajini Nagarajah3

  • 1Gene and Stem Cell Therapy Program Centenary Institute, Camperdown, NSW, Australia; Department of Clinical Immunology and Allergy, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Cytotherapy
|February 13, 2024
PubMed
概括

化学抗原受体 (CAR) 向美索林 (MSLN) 的T细胞根据MSLN密度表现出不同的疗效. 将CAR T细胞与MSLN-sheddase抑制剂结合起来,可以增强抗瘤活性,提供一种克服低抗原表达的策略.

关键词:
汽车 汽车 汽车 汽车抗原密度 抗原密度仿制性抗原受体T细胞的T细胞.梅索他林是其中一种.半质瘤 (Mesothelioma) 是一种中质瘤.胰腺癌是一种癌症.

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