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基于衍生的外体样纳米纤维的伤口包裹用于黄金葡萄球菌感染可视化和治疗

Sisi Zhou¹, Puzhen Huang¹, Yu Cao¹

¹Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.

ACS applied bio materials

|February 13, 2024

概括

装载着万科米的衍生纳米微粒提供可见的,可注射的水凝,用于治疗黄 Staphylococcus aureus 伤口感染. 这种治疗方法可以直接可视化和有效消除细胞内细菌.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
传染性疾病传染性疾病

背景情况:

黄金葡萄球菌 (S. aureus) 感染是具有挑战性的,因为免疫反应和抗生素的细胞内逃避.
在伤口中有效地在现场检测和治疗细胞内金黄色细菌是关键的未满足需求.
由大衍生的外体样纳米微粒 (GELNs) 显示出作为天然疗法和药物输送纳米载体的潜力.

研究的目的:

开发一种可见,可注射和热敏的水凝,用于S. aureus感染.
使用GELN作为纳米载体,用于向细胞内S. aureus.输送万科胺.
为了实现同时可视化和治疗S. aureus伤口感染.

主要方法:

制造一个对H2O2.2.有反应的Van@GELNs) 载有范素的GELNs/F127水凝.
通过RAW 264.7巨细胞对GELNs和Van@GELNs内部化的评估.
对S. aureus感染的小鼠伤口模型中的抗菌活性和治疗疗效的评估.
在水凝形成和治疗反应的现场可视化.

主要成果:

Van@GELNs水凝显示,与自由的菌素相比,对S. aureus有增强的抗菌活性.
范@GELNs有效地杀死了巨细胞内的细胞内金黄色细菌.
适应H2O2的水凝提供了放缓释放的万科米辛,并通过颜色变化实现了裸眼的感染可视化.
在小鼠模型中,治疗疗效超过了常规范科米辛治疗的疗效.

结论:

开发的Van@GELNs水凝是S. aureus伤口感染的有前途的治疗药物.
这种方法允许直接可视化和有效治疗细胞内细菌感染.
Van@GELNs凝具有未来临床应用的潜力,用于管理黄金色杆菌感染.

关键词:

对H2O2有反应性的黄金葡萄球菌感染黄金葡萄球菌感染抗微生物药物抗微生物药物由大制成的外体类似的纳米微粒.热敏水凝是一种热敏水凝.

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