对食物过敏和与食物相关的过敏症的管理
Edward G A Iglesia1, Mildred Kwan2, Yamini V Virkud3
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
JAMA
|February 13, 2024
概括
在美国,IgE介导的食物过敏很常见,影响数百万人. 与咬相关的阿尔法综合症是红肉严重过敏反应的原因之一, 需要谨慎避免并立即进行上腺素治疗.
科学领域:
- 过敏和免疫学
- 公共卫生
- 流行病学
背景情况:
- 美国有数以百万计的人患有IgE介导的食物过敏,
- 阿尔法-加尔综合征是一种IgE介导的对哺乳动物肉类 (alpha-gal) 的过敏,影响了大量人群,是成年人与食物相关的过敏的主要原因.
研究的目的:
- 总结美国IgE介导的食物过敏的流行,原因和治疗.
- 突出阿尔法综合征是与食物相关的过敏反应的重要原因.
主要方法:
- 对美国食物过敏的流行病学数据的审查.
- 对阿尔法综合征的流行率和临床意义的分析.
- 目前对食物过敏和α-gal综合征的管理策略的总结.
主要成果:
- 常见的食物过敏原包括贝类,乳制品,花生,树木坚果,鱼,蛋,小麦,大豆和芝麻.
- 在美国,阿尔法-加尔综合征影响96,000-450,000人,在某些地区的血清流行率高达31%.
- 与食物相关的过敏有较低的死亡率 (0.04每百万/年),但需要立即治疗.
结论:
- 常见的是IgE介导的食物过敏和α- gal综合征,可能导致危及生命的过敏反应.
- 治疗重点是避免过敏原 (对阿尔法综合征的食物和虫咬伤) 和及时服用上腺素.
- 新兴的免疫疗法为特定食物过敏提供了新的治疗途径,
相关概念视频
Allergic Reactions
27.4K
Overview
27.4K
Hypersensitivities
642
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
642
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-IV: Nursing Management
3.1K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.1K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
298
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
298


