在TAI后3天,服用长效注射性孕激素的补充剂,在水牛中损害了白色细胞功能
Diego Cavalcante de Souza1, Angela Maria Gonella-Diaza2, Nelcio Antonio Tonizza de Carvalho3
1Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
Tropical animal health and production
|February 13, 2024
概括
在定时人工授精 (TAI) 后3天服用长效注射性孕激素 (iP4) 会对水牛的生殖结果产生负面影响. 这种时间减少了黄体的发育,并降低了水牛母牛的整体怀孕率.
科学领域:
- 生殖生物学 生殖生物学
- 动物科学动物科学
- 内分泌学 在内分泌学.
背景情况:
- 孕激素对于在水牛中建立和维持怀孕至关重要.
- 了解孕激素补充的最佳时间对于改善水牛的生殖效率至关重要.
研究的目的:
- 评估长效注射性孕激素 (iP4) 在定时人工授精 (TAI) 后的不同时间给药对水牛牛的生殖参数的影响.
- 确定iP4对红色体 (CL) 发育,概念体,子宫内膜和怀孕结果的影响.
主要方法:
- 进行了三项涉及卵巢切除和哺乳水牛的实验.
- 300毫克和600毫克的IP4剂量被测试为血清度和持续时间.
- 在TAI后3天或6天服用iP4,随后对生殖道,CL,子宫内膜和怀孕率进行分析.
主要成果:
- 在注射后大约3天内,血清孕激素度保持在1ng/mL以上.
- 与对照组和iP4-D6.6相比,在TAI (iP4-D3) 后3天服用iP4导致CL重量和子宫内膜腺密度降低,并增加受胎体长度.
- 根据IP4-D3治疗,FP,ISG15和MX1的基因表达在CL和子宫内膜中发生了改变.
- 虽然在第30天没有观察到每次AI (P/TAI) 怀孕的差异,但在第60天,iP4-D3显示出较低P/TAI的趋势.
结论:
- 在TAI后3天服用iP4会对水牛的CL发育和子宫内膜功能产生负面影响.
- 这种早期的妊娠后孕激素补充可以降低水牛牛的最终妊娠结果.
- 孕激素的时间对雄牛成功怀孕至关重要.
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