Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
Inflammation01:38

Inflammation

53.4K
Overview
53.4K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
30
The Blood-brain Barrier00:49

The Blood-brain Barrier

47.4K
Overview
47.4K
Neural Regulation01:37

Neural Regulation

39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Advances in metabolomics of biomarkers for ischemic stroke: From bench to clinic.

Neural regeneration research·2025
Same author

Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.

Scientific reports·2016
Same author

Computational Analysis of Structure-Based Interactions for Novel H₁-Antihistamines.

International journal of molecular sciences·2016
Same author

Mixed Spectrum Analysis on fMRI Time-Series.

IEEE transactions on medical imaging·2016
Same author

Ultra-Low Power Dynamic Knob in Adaptive Compressed Sensing Towards Biosignal Dynamics.

IEEE transactions on biomedical circuits and systems·2016
Same author

Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1.

Journal of immunology (Baltimore, Md. : 1950)·2016

相关实验视频

Updated: Jul 3, 2025

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.2K

撕裂和神经炎症 撕裂和神经炎症

Yue Xu1, Feng Lin1, Guolei Liao1

  • 1Department of Cerebrovascular Disease, Sun Yat-Sen University, The Fifth Affiliated Hospital, Zhuhai, 519000, Guangdong, People's Republic of China.

Molecular neurobiology
|February 13, 2024
PubMed
概括

神经炎症涉及到受体氨酸/氨酸蛋白激酶 (RIPK) 家族. 这篇评论探讨了RIPK1,RIPK2和RIPK3作为阿尔茨海默氏症和帕金森症等神经炎症疾病的治疗点.

关键词:
神经炎症是一种神经炎症.在RIPK1中使用.在RIPK2中使用RIPK2.在RIPK3中使用RIPK3.

更多相关视频

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

1.8K

相关实验视频

Last Updated: Jul 3, 2025

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.2K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

1.8K

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 神经炎症是各种神经疾病的关键因素.
  • 受体氨酸/氨酸蛋白激酶 (RIPK) 家族在炎症过程中发挥着关键作用.
  • 现有的研究主要集中在RIPK1上,忽视了对神经炎症中RIPK家族的全面分析.

研究的目的:

  • 系统地分析RIPK家族在神经炎症中的作用.
  • 探索RIPK1,RIPK2和RIPK3在治疗神经炎症疾病中的治疗潜力.
  • 将RIPK家族成员与阿尔茨海默病 (AD),帕金森病 (PD) 和多发性硬化症 (MS) 等特定疾病联系起来.

主要方法:

  • 文献综述和对RIPK家族成员和神经炎症现有研究的分析.
  • 检查涉及RIPK1,RIPK2和RIPK3在炎症通路中的分子机制.
  • RIPK活动与细胞死亡途径 (亡,亡) 和免疫信号 (NF-κB,MAPK) 的相关性.

主要成果:

  • RIPK1和RIPK3直接参与调节细胞死亡和释放与损伤相关的分子模式 (DAMPs),促进神经炎症.
  • 激活的RIPK1可以转移到核中,影响染色质修饰和炎症基因表达.
  • 虽然RIPK2没有直接调节细胞死亡,但通过无处不在化级联激活NF-κB和MAPK通路,从而导致细胞因子的产生.

结论:

  • RIPK1和RIPK3是神经炎症和细胞死亡的关键媒介.
  • RIPK2在与神经疾病相关的细菌诱导炎症反应中充当关键信号节点.
  • RIPK1,RIPK2和RIPK3代表了神经炎症疾病的有希望的治疗点,包括AD,ALS,缺血性中风,PD,MS和TBI.