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在青春期后未下降的丸中,丸生殖细胞瘤和精子生成失败的风险
Rifat Burak Ergül1, Zeynep Bayramoğlu2, Avni Merter Keçeli3
1Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Çapa Fatih, 34093, Istanbul, Turkey.
International urology and nephrology
|February 13, 2024
概括
对于未下降的丸的青春期后桃切除术显示,丸生殖细胞瘤的发生率为4%. 没有一个丸显示出正常的精子生成,这表明雄心切除术是青春期后男性的可行选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
背景情况:
- 密码体 (未下降的丸) 是丸生殖细胞瘤 (TGCTs) 的已知危险因素.
- 建议早期进行兰花术以改善生育能力和降低癌症风险,但青春期后的治疗仍然存在争议.
- 了解未经治疗的密码症的组织病理学和精子生成对于临床决策至关重要.
研究的目的:
- 来自未经治疗的密封性症的青春期后患者的兰花切除样本的组织病理学审查.
- 为了确定这些患者的精子生成的存在.
- 为了评估TGCTs在这个特定的患者群体中的风险.
主要方法:
- 回顾性图表审查的青春期后的个人经历了 inguinal orchiectomy 为未下降的丸 (2010-2019).
- 评估手术时的年龄,横向性,丸位置和病理学结果.
- 盲目病理学家对所有病理学标本的组织学审查.
主要成果:
- 该队列包括23名患者 (平均年龄21岁;年龄范围13-46岁),所有患者都有 inguinal 丸.
- 一名患者 (4%) 被诊断为半瘤.
- 在所有没有瘤的22名患者中,没有正常的精子生成;19名患者缺乏精子管道,而3名患者的成熟停止.
结论:
- 丸生殖细胞癌发生在4%的青春期后患者中,这些患者接受了为未下降的丸进行桃切除术.
- 在这个队列中,没有一个未下降的丸表现出正常的精子生成活性.
- 在处于青春期后的男性中,如果他们的丸单侧未下降,不需要内分泌功能,则应考虑进行精管切除术.
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