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移植期间的外科手术平衡晶体与正常盐水相比:随机对照试验的系统审查和元分析
Muhammad Imran1, Yehya Khlidj2, Ahmed Naeem3
1University College of Medicine and Dentistry, The University of Lahore, Lahore, Pakistan.
International urology and nephrology
|February 13, 2024
概括
均衡晶体 (BC) 与正常盐水 (NS) 相比,在移植 (KT) 患者中显著降低延迟移植功能 (DGF). BC还可以改善术后的酸平衡,降低化物水平,优化KT结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 关键护理医学 关键护理医学
背景情况:
- 在移植 (KT) 手术中,术后静脉注射液的使用至关重要,因为它会影响移植的功能.
- 在液体治疗中,平衡晶 (BC) 和正常盐水 (NS) 之间的选择可能会影响KT后的结果.
- 本元分析评估了BC与NS对KT结果的比较影响.
研究的目的:
- 评估外科手术期间平衡水晶体 (BC) 与正常盐水 (NS) 对移植后 (KT) 结果的影响.
- 评估不同类型的输液液对移植功能和酸平衡的影响.
- 提供基于证据的建议,用于KT接受者的流体管理.
主要方法:
- 在五个数据库中对相关的随机对照试验 (RCT) 进行了系统的文献搜索.
- 数据选和合成使用Covidence和RevMan 5.4软件进行.
- 使用元分析汇集数据,计算风险比率 (RR) 和平均差异 (MD) 以95%的置信区间 (CI).
主要成果:
- 对15项涉及2,008名参与者的RCT的分析显示,BC的延迟移植功能 (DGF) 显著降低 (RR:0.78,P=0.0009).
- 与NS相比,BC给药导致术后血液pH值显著提高 (MD:0.05,P<0.01) 和血清化物水平降低 (MD: -7.31,P<0.01) 和水平降低 (MD: -1.94,P=0.006).
- 在POD1和POD7之间没有观察到血清,血清肌或尿液输出的显著差异.
结论:
- 均衡晶体 (BC) 在移植后减少延迟移植功能 (DGF) 的显著益处.
- 与正常盐水 (NS) 相比,BC的使用促进了更稳定的术后酸参数,并减少了高血症.
- 用BC取代NS是一种可行的策略,可以减轻酸性和高性侮辱,从而优化移植结果.
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