药物遗传检测的机会,以指导医疗补助的年轻人服用药物的剂量
Sonya Tang Girdwood1,2,3, Matthew Hall4, James W Antoon5,6
1Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
在医疗补助保险的年轻人中,药物遗传学指导 (PGx) 药物的使用从2011年到2019年大幅增加. 这凸显了对通常处方的PGx药物进行向药物遗传学测试的必要性.
科学领域:
- 药物基因组学 药物基因组学
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 越来越多的药物具有高水平的药物遗传学指导剂量 (PGx药物) 证据.
- 了解PGx药物分发和相关基因的流行率对于在医疗保健机构实施药物遗传学测试至关重要.
研究的目的:
- 调查医疗补助保险的年轻人中门诊PGx药物分发的流行情况.
- 为了识别与PGx药物处方最频繁相关的基因.
- 描述接受至少一种PGx药物的青少年的特征.
主要方法:
- 一个连续的横截面研究,使用来自Marketscan医疗补助数据库 (2011-2019) 的数据.
- 根据临床药物遗传学实施联盟 (CPIC) 的A级证据,PGx药物被定义为A级证据.
- 根据相关基因分组的PGx药物,确定了每10万名年轻人分发的发行率.
主要成果:
- 获得医疗补助保险的青少年分发PGx药物的比例从2011年的13.9%上升到2019年的17.9%.
- 在PGx药物分发中,CYP2C9,CYP2D6和CYP2C19是最经常涉及的基因.
- 与未服用PGx药物 (40.8%) 相比,服用PGx药物的青少年更有可能患有慢性病 (69.0%).
结论:
- 在医疗补助保险的年轻人中,PGx药物发行量显著增加.
- 应考虑对经常处方的PGx药物及其相关基因进行药物遗传学测试.
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