中性粒细胞与淋巴细胞的比率与成人冠心病风险有关:基于人口的研究
Yu Wang1,2,3,4,5, Yangping Zhuang1,2,3,4,5, Changsha Lin6
1Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
PloS one
|February 13, 2024
概括
中性粒细胞与淋巴细胞比率升高与冠状动脉心脏病风险增加有关. 这一发现突显了该比率作为心血管疾病的潜在生物标志物.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 中性粒细胞-淋巴细胞比率 (NLR) 是一个新兴的炎症标志物.
- 它与心血管疾病,特别是冠心病 (CHD) 的关联需要进一步调查.
研究的目的:
- 为了检查NLR和CHD风险之间的关系.
- 识别潜在的非线性关联和更高风险的特定子组.
主要方法:
- 来自NHANES的13,732名美国成年人 (≥40岁) 的横截面研究.
- 多变量逻辑回归和光滑曲线拟合分析了NLR和CHD风险.
- 递归方法确定了非线性关系的拐点.
主要成果:
- 较高的NLR独立地与较高的心脏病风险相关 (OR=1.74,P=0.0002).
- 在女性,老年人 (≥60岁),吸烟者,中度饮酒者,肥胖者 (BMI>30),高血压患者和非糖尿病患者中观察到显著的积极关联.
- 滑曲线拟合显示出与NLR=1.08 (P<0.05) 的拐点有显著的正相关性.
结论:
- 较高的NLR水平与冠状动脉心脏病风险增加有显著联系.
- NLR可能作为CHD的有价值的预测生物标志物,特别是在特定的人口统计和临床子组.
- 需要进一步的研究来探索NLR在心血管健康中的潜在机制和临床应用.
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