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咖啡因饮料摄入量和深静脉血栓形成风险:孟德尔的随机化研究

Tong Lin¹, Haiyan Mao¹, Yuhong Jin¹

¹Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital Ningbo, Zhejiang, The People's Republic of China.

|February 13, 2024

概括

咖啡消费可能与深静脉血栓症 (DVT) 的风险略有增加有关. 然而,根据这项遗传研究,茶的摄入似乎不会显著影响DVT风险.

科学领域:

心血管流行病学心血管流行病学
遗传流行病学遗传流行病学
药物遗传学药物遗传学

背景情况:

深静脉血栓症 (DVT) 是一种严重的血管疾病.
了解饮料消费等生活方式因素对DVT风险的影响对于公共卫生至关重要.
之前的观察性研究已经产生了关于咖啡和茶的消费和DVT不一致的结果.

研究的目的:

调查咖啡和茶的消费和深静脉血栓塞 (DVT) 的风险之间的潜在因果关系.
利用门德尔的随机化 (MR) 分析来对这种关联进行可靠的评估,最大限度地减少混因素.

主要方法:

孟德尔随机化 (MR) 分析使用单核酸多态 (SNP) 作为咖啡和茶摄入量的仪器变量进行.
反变量加权 (IVW) 方法是主要的分析方法.
我们使用MR-Egger,MR-PRESSO,Cochran的Q测试和离开一个的分析来评估型,异质性和强度.

主要成果:

在咖啡摄入量与增加DVT风险 (OR 1.008,P=0.025) 之间发现了温和而具有统计意义的关联.
没有观察到茶饮对DVT风险的显著因果关系 (OR 1.001,P=0.735).
仪表变量没有显示出显著的异质性,排列性或偏差.

结论:

咖啡消费与深静脉血栓形成的风险略微增加有关.
茶饮似乎对DVT风险没有显著的因果关系.
这些发现支持使用MR来评估饮食习惯对血栓事件的影响.

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