偏头痛,血管运动症状和心血管疾病在冠状动脉风险发展在年轻成年人研究的研究
Catherine Kim1, Pamela J Schreiner2, Zhe Yin3
1From the Departments of Medicine, Obstetrics and Gynecology, and Epidemiology, University of Michigan, Ann Arbor, MI.
偏头痛和女性持续的血管运动症状 (VMS) 与心血管疾病 (CVD) 和中风风险增加有关. 当考虑传统的心血管疾病风险因素时,这种关联会减少.
科学领域:
- 心血管流行病学心血管流行病学
- 神经学 神经学
- 妇女健康 妇女健康
背景情况:
- 血管运动症状 (VMS) 和偏头痛在女性中很常见,并被假设为血管活性状况.
- 了解它们与心血管疾病 (CVD) 风险的关联对于预防策略至关重要.
研究的目的:
- 调查偏头痛,VMS轨迹和心血管事件 (包括中风) 的风险之间的关联.
- 为了确定这些关联是否在调整传统心血管疾病风险因素后仍然存在.
主要方法:
- 从年轻成年人冠状动脉风险发展研究 (CARDIA) 中对1,954名女性的二次数据分析.
- 检查了VMS轨迹 (最小,增加,持久) 和偏头痛史.
- 使用Cox比例危险回归,调整心血管疾病风险因素和生殖因素.
主要成果:
- 患有偏头痛史和持续性VMS的女性患心血管疾病和中风的风险更高.
- 经过对传统心血管疾病风险因素进行调整后,这些关联得到了减弱.
- 特定危险比率 (HR) 表示风险增加,尽管经过调整后的置信区间重叠为1.
结论:
- 偏头痛和持续的VMS共同与心血管疾病和中风的风险增加有关.
- 观察到的风险部分是由传统的心血管风险因素解释的.
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