慢性活跃病变和较大的胆管解释了多发性硬化症的认知和疲劳
Paolo Preziosa1, Elisabetta Pagani1, Alessandro Meani1
1From the Neuroimaging Research Unit (P.P., E.P., A.M., L.S., M.M., Y.Y., N.T., D.B., M.R., M.A.R., M.F.), Division of Neuroscience; Neurology Unit (P.P., M.M., M.R., M.A.R., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (P.P., M.R., M.A.R., M.F.); Neurorehabilitation Unit (M.M., M.F.); and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology(R) neuroimmunology & neuroinflammation
|February 13, 2024
概括
慢性炎症标志物,包括偏磁边缘病变 (PRLs) 和扩大胆膜 (CP),与多发性硬化症 (MS) 的认知障碍有关. 扩大的CP还预测疲劳,表明免疫过程会影响这些MS症状.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性炎症与多发性硬化症 (MS) 的认知功能障碍和疲劳有关.
- 偏磁边缘病变 (PRLs) 和胆脉 (CP) 扩大是MS中慢性炎症的建议标志物.
- 在MS中,PRLs,CP扩大和认知/疲劳症状之间的关系需要进一步研究.
研究的目的:
- 为了调查对磁边损伤 (PRL) 数量和体积以及状 (CP) 扩大对多发性硬化症 (MS) 患者认知障碍和疲劳的贡献.
主要方法:
- 129名MS患者和73名健康对照 (HC) 接受了脑部3TMRI,神经学评估和神经心理测试.
- 在敏感度加权成像上确定了PRL,自动量化了CP体积.
- 随机森林分析被用来确定认知障碍和疲劳的预测因素.
主要成果:
- 在27.9%的MS患者中存在认知障碍;疲劳在27.4%中存在.
- 认知障碍的预测因素包括正常化的大脑体积,正常化的尾状体积,正常化的CP体积,正常化的皮质体积,PRL数量和体积,以及白质病变体积.
- 正常化的CP体积是疲劳的唯一预测因素.
结论:
- 慢性炎症,以PRLs和扩大的CP表示,可能会导致MS的认知障碍,以及灰质缩.
- 扩大的CP与疲劳有关,这表明与免疫相关的过程独立地影响了这种症状.
- PRL和CP扩大可能是MS病理生理学的关键,并代表认知和疲劳症状的潜在治疗点.
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