睡眠特征和中风和痴呆风险:一个观察性和门德尔随机化研究
Chutian Guo1, Eric L Harshfield1, Hugh S Markus1
1From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.
Neurology
|February 13, 2024
概括
睡眠质量差,包括失眠和小睡,与中风和痴呆症风险更高有关. 然而,因果关系是不确定的,这表明潜在的混因素而不是痴呆的直接原因.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 睡眠障碍是已知的中风和痴呆的危险因素.
- 睡眠问题与这些神经疾病之间的因果关系尚不清楚.
- 治疗睡眠障碍以减轻中风和痴呆风险的潜力是不确定的.
研究的目的:
- 评估睡眠特征与中风和痴呆风险之间的关联.
- 确定睡眠模式,中风/痴呆风险和小血管疾病 (SVD) 的MRI标志物之间的因果关系.
- 通过使用孟德尔随机化来研究遗传倾向在与睡眠相关的神经风险中的作用.
主要方法:
- 利用来自502,383名参与者的大型,多中心,基于人口的研究 (英国生物库) 的数据.
- 采用了对发生中风,痴呆症和SVD标记物的观察分析,并根据关键风险因素进行调整.
- 使用全基因组关联研究 (GWAS) 数据进行孟德尔随机化 (MR) 分析以推断因果关系.
主要成果:
- 在纵向分析中,失眠,白天小睡和沉睡与中风风险增加有关.
- 大多数睡眠测量结果显示与痴呆症风险存在关联,尽管失眠的联系不那么明显.
- 午睡和打与小血管疾病 (SVD) 的MRI标志物有关.
- 核磁共振分析表明,基因预测的失眠和中风风险增加之间存在潜在的因果关系.
- 在基因预测的睡眠特征和痴呆症或SVD标志物之间没有发现显著的因果关系.
结论:
- 虽然观察数据表明,睡眠测量可以预测中风和痴呆风险,但当控制心血管因素时,这些关联会减弱.
- 门德尔随机化分析没有支持阿尔茨海默病的因果关系,这表明潜在的混或反向因果关系.
- 根据当前的证据,建议谨慎采取针对睡眠障碍的干预措施,以预防或治疗痴呆症.
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