在孕前症中的血管性生物标志物
Richard M Burwick1, M Hellen Rodriguez
1Division of Maternal Fetal Medicine, San Gabriel Valley Perinatal Medical Group, Pomona Valley Hospital Medical Center, Pomona, California.
Obstetrics and gynecology
|February 13, 2024
概括
孕前症是孕产妇和婴儿并发症的主要原因,可以使用血管原生生物标志物进行预测. 可溶性fms类氨酸激酶1 (sFlt-1) 与胎盘生长因子 (PlGF) 的比率有助于预测具有严重特征的妊娠前.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 生殖生物学 生殖生物学
背景情况:
- 孕前症在全球显著增加了孕产妇和新生儿的发病率和死亡率.
- 血管新生失衡是孕前的关键因素,通常会在临床症状之前出现.
- 胎盘衍生的血管原生生物标志物,可溶性fms类铁酶-1 (sFlt-1) 和胎盘生长因子 (PlGF),对于早期检测至关重要.
研究的目的:
- 审查支持sFlt-1/PlGF测定用于预产前的证据.
- 讨论sFlt-1/PlGF比率在治疗妊娠高血压疾病中的临床应用.
- 突出这一试验在优化护理和减少产前的不良结果方面的作用.
主要方法:
- 关于sFlt-1和PlGF在孕前中的研究的叙述性综述.
- 科学工作的总结导致FDA批准sFlt-1/PlGF测定.
- 对sFlt-1/PlGF比率的临床实用性和实施策略的讨论.
主要成果:
- sFlt-1/PlGF测定被FDA批准用于预测患有高血压疾病的女性患有严重特征的孕前.
- 这种测试有助于在明显疾病表现之前的几个星期到几个月内预测子前症.
- sFlt-1/PlGF比率已经证明作为诊断和预后工具的实用性.
结论:
- sFlt-1/PlGF试验在预测和治疗子宫前方面取得了重大进展.
- 对sFlt-1/PlGF比率的临床实施可以优化患者护理并减少不良结果.
- 这种生物标志物比率是临床预先怀孕的有价值的辅助措施.
更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
820
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
10.7K
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
01:10Mechanism of Angiogenesis
5.5K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.5K