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在Nellore牛群中,全基因组关联和功能性注释分析用于分娩间隔

Mayra Silva Dias¹, Victor Breno Pedrosa², Valdecy Aparecida Rocha da Cruz¹

¹Federal University of Bahia, Animal Science Department, Av. Milton Santos, 500, Ondina, Salvador, BA, 40170-110, Brazil.

|February 13, 2024

概括

尼罗尔牛的分娩间隔具有较低的遗传性,估计为0.04. 全基因组关联研究在BTA13上发现了重要的SNP,揭示了影响这种重要的生殖特征的复杂遗传因素.

科学领域:

动物遗传学动物遗传学
生殖生物学生殖生物学
基因组选择基因组选择

背景情况:

产卵间隔 (CI) 是牛的关键生殖特征,影响着牛群的生产力.
之前的研究表明,使用表型和血统数据,CI的遗传性较低.
使用基因组数据的内罗尔牛的CI遗传结构在很大程度上仍未被探索.

研究的目的:

通过基因组数据估计内罗尔牛的分娩间隔的遗传性.
为了在这个品种中进行全基因组关联研究 (GWAS) 进行分娩间隔.
为了识别与分娩间隔相关的遗传标记和生物途径.

主要方法:

使用了血统记录 (12,599),CI记录 (5078) 和SNP基因定型 (3818只动物,50k个SNPchip).
在BLUPF90中使用单步基因组最佳线性无偏预测器 (ssGBLUP) 方法进行质量控制和GWAS.
执行了重要的SNP的功能注释,以识别候选基因.

主要成果:

对CI的遗传性估计很低 (0.04 ± 0.04).
在全基因组层面上,在BTA13上发现了一个显著的SNP (rs136725686).
19个额外的SNP达到全染色体的意义,36个蛋白质编码基因参与了各种生物过程.

结论:

尼罗尔牛的分娩间隔是一种复杂的特征,具有较低的遗传性.
基因组数据揭示了与CI相关的显著遗传标记,突出了细胞周期,卵细胞功能,免疫力和内分泌信号传递中的作用.
对这些生物通路的进一步研究可以有助于提高内罗尔牛的生殖效率.

关键词:

牛群是牛群,牛群就是牛群.基因基因基因基因遗传性遗传性是可以继承的.生殖生殖的繁殖国家统一计划 (SNP) 是一个国家统一计划.塞布·泽布 (Zebu Zebu) 是一个名字.

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