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来自中国的负担得起的血液培养系统:用于资源有限的环境中的体外评估

Liselotte Hardy¹, Tine Vermoesen¹, Els Genbrugge¹

¹Institute of Tropical Medicine (ITM), Antwerp, Belgium.

|February 13, 2024

概括

价格实惠的中国持续监测血液培养系统 (CMBCS) 在资源有限的环境中显示出高性能诊断血液感染 (BSI). 这些系统为昂贵的设备提供了可行的替代方案,改善了全球的BSI诊断.

科学领域:

医学诊断医学诊断医学诊断
微生物学微生物学
全球健康全球健康

背景情况:

血流感染 (BSI) 每年导致数百万人的死亡,由抗菌素耐药性 (AMR) 加剧.
由于成本和环境因素,资源有限的环境 (RLS) 在实施先进的诊断工具方面面临重大挑战,例如持续监测血液培养系统 (CMBCS).
新兴制造商提供负担得起的体外诊断,可能弥合RLS的差距.

研究的目的:

评估中国CMBCS的性能,可用性和可互换性.
评估这些系统在资源有限的环境中适用于血液感染诊断.

主要方法:

使用模拟血液培养物对四种中国CMBCS (Autobio BC60,Mindray TDR60,Scenker Labstar50,DL-biotech DL-60) 的实验室评估.
使用20个BSI相关菌株的小组进行测试.
与参考系统进行比较,并在手动血液培养模式下进行评估.

主要成果:

所有评估的CMBCS都表现出高性能 (收益率为96.7-100%,特异性为97.5-100%),与参考系统相比.
在传统化器中手动使用也产生了令人满意的结果 (产量90-100%,特异性100%).
不同品牌的BCB (除了Scenker) 显示与自动机互换性,表明一个通用BCB的潜力.

结论:

推在具有挑战性的环境和资源有限的环境中使用.
自动生物系统在自动检测方面表现出色,DL-Biotech BCB在手动培养中表现出色,考虑到性能,价格和可用性.
需要实地研究来确认RLS的适用性.

关键词:

血液培养是一种血培养.不断监测血液培养系统的持续监测评估研究评估研究资源有限的设置设置.

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