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益生菌配方的GABA肠道生产:一个体外研究
M Casertano1,2, C Fryganas2, V Valentino1
1Department of Agricultural Sciences, University of Naples, 'Federico II', Università 100, 80055 Portici, Italy.
Beneficial microbes
|February 13, 2024
概括
这项研究发现,一种特定的益生菌配方增加了肠道中的胺黄油酸 (GABA) 和乙胆的产生. 益生菌还改变了肠道微生物群的组成,显示出作为精神病菌的潜力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在产生神经活性化合物方面发挥着至关重要的作用.
- 某些益生菌菌株已经显示出调节肠-大脑轴的潜力.
- 了解益生菌对神经递质产生的影响,对于开发精神病菌来说至关重要.
研究的目的:
- 评估益生菌配方对结肠中神经活性化合物产生的影响.
- 评估益生菌对肠道微生物群组成和短链脂肪酸 (SCFA) 生产的影响.
- 为了研究精选的乳酸细菌菌株的精神生物潜力.
主要方法:
- 使用了体外批量培养和人类肠道微生物群 (SHIME®) 模拟器实验.
- 通过LC-MS测量神经递质 (GABA,乙胆).
- 短链脂肪酸 (SCFA) 被GC分析.
- 微生物群组成由16S rRNA基因测序确定.
主要成果:
- 益生菌补充剂增加了胺黄油酸 (GABA) 和乙胆的产生,同时在体外减少了谷氨酸水平.
- 在益生菌治疗后的SHIME®模型中证实了GABA的产生.
- 益生菌暴露导致了更丰富的Bacteroides,与抗炎性质和GABA生产相关的微生物.
- 在72小时内没有观察到SCFA水平的显著变化.
结论:
- 测试的益生菌配方有效调节了肠道微生物群的组成,并增强了像GABA这样的神经活性代谢物的产生.
- 这些发现表明,益生菌配方具有有前途的精神生物潜力.
- 需要进一步的临床研究来验证这些益生菌在改善心理健康方面的有效性.
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