一种益生菌氨基酶混合物在一项随机临床研究中减少了胃肠道症状
M B La Monica1, B Raub1, H L Lopez1
1The Center for Applied Health Sciences, 6570 Seville Dr., Canfield, OH 44406, USA.
Beneficial microbes
|February 13, 2024
概括
与安慰剂相比,益生菌-氨酶混合物显著改善了胃肠道症状,包括胀气和腹部不适. 这种混合物为管理常见的消化问题提供了耐受性良好的选择.
科学领域:
- 胃肠道学和微生物学
- 临床营养学 临床营养学
- 人类健康和疾病
背景情况:
- 胃肠道 (GI) 症状很普遍,影响生活质量.
- 益生菌和酶补充剂正在探索用于管理胃肠道不适.
- 一种新的益生菌-氨酶混合物需要临床评估其有效性.
研究的目的:
- 评估益生菌-氨酶 (PRO) 混合物在减轻胃肠道症状方面的有效性.
- 为了比较PRO补充剂与安慰剂 (PLA) 在轻度至中度胃肠道问题的个体中的效果.
- 评估PRO对整体幸福感和焦虑程度的影响.
主要方法:
- 一个随机的,安慰剂控制的,双盲的,并行临床研究.
- 60名患有轻度至中度胃肠道症状的参与者被随机分配给PRO或PLA治疗6周.
- 胃肠道指数,GSRS,GAD-7和SF-36问卷被用于基线和补充后的评估.
主要成果:
- 与安慰剂相比,益生菌-氨酶混合物显著降低了胃肠道症状评分表 (GSRS) 评分,胀气和腹部不适.
- 在GSRS得分 (∼60%对25%),膨胀 (∼49%对25%) 和腹部不适 (59%对32%) 中观察到有统计学意义的改善.
- 此外,PRO补充剂还导致主观易怒,疼痛和整体健康干扰的感觉减少,没有报告任何不良影响.
结论:
- 益生菌-氨酶混合物有效地减少了常见的胃肠道症状,包括胀气和腹部不适.
- 这种混合物在改善胃肠道症状严重程度和患者报告结果方面表现出比安慰剂更高的疗效.
- 口服补充益生菌-氨酶混合物是一种安全且耐受良好的干预措施,用于控制胃肠道症状.
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