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PCL/纤维素酸纳米纤维的糖尿病伤口愈合功能是用奇托/氧化纳米颗粒进行工程设计的

Samaneh Kamalipooya¹, Shohreh Fahimirad², Hamid Abtahi²

¹Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran; Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

International journal of pharmaceutics

|February 13, 2024

概括

这项研究开发了一种新的纳米纤维伤口包裹,使用氧化物纳米粒子 (CeO₂NPs) 封装在基托纳米粒子中. 先进的敷料显著加速糖尿病伤口愈合,并表现出强大的抗菌和抗氧化特性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
伤口愈合治愈伤口愈合

背景情况:

氧化纳米颗粒 (CeO₂NP) 显示出糖尿病伤口修复的潜力.
需要一种新的基于纳米的伤口包裹来提高愈合效率.
基托纳米颗粒提供了一个适合封装治疗剂的矩阵.

研究的目的:

引入一种基于纳米的新型伤口包裹,将绿色合成的氧化纳米粒子 (CeO₂NPs) 纳入基托纳米粒子 (CeO₂-CSNPs) 中.
评估开发的电纳米复合材料的物理化学,形态学和生物特性.
评估纳米复合材料在促进糖尿病伤口愈合方面的有效性.

主要方法:

绿色合成的CeO₂NP使用菌素提取物.
将CeO₂NP封装成奇托纳米颗粒 (CeO₂-CSNP) 的方法.
制造PCL/纤维素酸 (PCL/CA) 的电纳米纤维膜.
通过电喷将CeO₂-CSNP集成到PCL/CA膜上.
使用XRD,DLS,FESEM和FTIR进行表征.
在体外评估抗菌活性,抗氧化活性,细胞活力和细胞迁移.
在动物模型中对糖尿病伤口愈合的体内评估.

主要成果:

CeO₂-CSNP表现出理想的物理和结构性质.
在PCL/CA/CeO₂-CSNPs纳米复合体显示显著的抗菌活性对黄金色.
纳米纤维敷料显示高抗氧化活性 (89.59%),提高了细胞活力,增强了细胞迁移 (48小时后90.3%).
在体内研究显示,糖尿病患者的伤口修复率在15天后高达95.47%.

结论:

开发的PCL/CA纳米纤维地毯与CeO₂-CSNPs功能化,有效促进糖尿病伤口愈合.
纳米复合材料带具有显著的抗菌,抗氧化和促进细胞的特性,有利于伤口修复.
这种新的基于纳米的伤口包裹具有治疗糖尿病相关伤口的巨大潜力.

关键词:

纤维素乙酸盐的使用情况氧化纳米粒子是氧化的纳米粒子.基托桑是一种酸盐.电气喷雾是一种电子喷雾.电子制的纳米纤维.聚 (ɛ-caprolactone) 乙烯酸盐是一种多 (ɛ-caprolactone) 的化合物.伤口愈合伤口愈合

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