夜间人工光线与妊娠期糖尿病之间的关联:来自中国的前性队列研究
Junhao Liao1, Chuan Yu1, Jiarui Cai1
1Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University.
在怀孕期间暴露在夜间的大量室外人工光线 (ALAN) 与妊娠期糖尿病 (GDM) 的风险增加有关. 这项研究表明,ALAN是一种潜在的,可修改的GDM风险因素.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 新出现的证据将夜间户外人工光 (ALAN) 与糖尿病联系在一起.
- 关于户外ALAN和妊娠期糖尿病 (GDM) 之间的关联存在有限的研究.
研究的目的:
- 调查怀孕期间户外ALAN暴露与发展GDM的风险之间的关系.
- 探索ALAN暴露和GDM之间的潜在非线性关联.
主要方法:
- 利用来自中国四川省的一个队列研究的数据 (n=9,120).
- 使用卫星数据估计的户外ALAN暴露 (约. 500x500米的分辨率).
- 采用多变量逻辑回归和受限制的立方线,调整混因子.
主要成果:
- 16.27%的女性患上了GDM.
- 患有GDM的女性的平均室外ALAN暴露率显著更高.
- 较高的ALAN暴露增加了GDM风险 (或1.253对于第一和第二季度).
- 观察到一个非线性关联,ALAN成为约17.9nW/cm2/sr1.2的风险因素.
结论:
- 在怀孕期间,高户外ALAN暴露与GDM风险增加有关.
- 在ALAN暴露和GDM风险之间存在非线性关系.
- 户外ALAN代表了GDM的新兴,可修改的风险因素.
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