来自饮用水和饮食来源的酸盐暴露在使用私人井的爱荷华州农民中
Timothy G Skalaban1, Darrin A Thompson2, Jessica M Madrigal3
1Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, United States of America; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, United States of America.
The Science of the total environment
|February 13, 2024
概括
饮食来源贡献了大部分酸盐摄入量,但饮用水也很重要,特别是当井水超过MCL时. 两者都会影响尿中酸盐水平.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 美国水资源中酸盐水平的上升带来健康风险,甚至低于MCL.
- 饮食中酸盐通常与健康益处有关,与水中暴露形成鲜明对比.
- 饮食和饮用水中酸盐的联合暴露存在有限的研究.
研究的目的:
- 评估使用私人井的农民在饮用水和饮食来源中的酸盐暴露.
- 评估每个来源对酸盐总摄入量和尿路酸盐分泌量的贡献.
- 了解脆弱人群中酸盐摄入量和尿酸酸盐水平之间的关系.
主要方法:
- 爱荷华州东部47名农民使用私人井的前性队列研究 (2018-2019).
- 通过国家癌症研究所自动自主24小时饮食评估工具评估的酸盐摄入量.
- 在2010-2017年和2018-2019年的样本中测量了尿酸酸;分析了自来水酸.
主要成果:
- 饮食中酸盐是总摄入量的主要来源 (中位数为97%).
- 对于含酸盐≥MCL的参与者来说,水对摄入量的中位数为44%.
- 总酸盐摄入量强烈预测尿酸盐 (R2=0.53);水 (R2=0.52) 和饮食 (R2=0.47) 解释了排泄的类似变化.
结论:
- 饮食和饮用水都是酸盐分泌的关键决定因素.
- 私人井水中的高酸盐含量显著导致整体暴露.
- 公共卫生战略应考虑饮食和水中酸盐来源.
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