评估肠道微生物群对来自阿罗尼亚和蔓越的寡合和聚合类黄-3-的代谢能力
Jacob Lessard-Lord1,2,3, Charlène Roussel1,2,4, Valérie Guay1,2
1Institute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, Québec, QC, G1V 0A6, Canada.
Molecular nutrition & food research
|February 13, 2024
概括
阿罗尼亚和蔓越中的黄素-3-ols被肠道微生物代谢不良,转化率不到1%. 它们的健康益处可能来自与肠道微生物群和上皮的相互作用,而不是代谢物的分解.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于flavan-3-ols的临床试验结果因个人肠道微生物群的差异而有所不同.
- 人口群体对 (-) - 史基甲素和 (+) - 甲素具有相似的代谢特征,称为代谢类型.
研究的目的:
- 通过肠道微生物群来研究来自和蔓越的黄素-3-的体外和体内代谢.
- 为了确定黄素-3-ols是否转化为微生物代谢物,如基-γ-甲酸 (PVLs).
主要方法:
- 在体外便批发发酵中使用34个捐赠者.
- 在补充4天的蔓越提取物之前和之后,尿样中的肠道微生物代谢物的量化.
主要成果:
- 在实验室中,不到1%的来自香和蔓越的黄-3-ols被转化为微生物代谢产物.
- 在体内补充蔓越后,没有观察到微生物中flavan-3-ol代谢物的尿液分泌的显著差异.
结论:
- 阿罗尼亚和蔓越中的黄素-3-ols被肠道微生物群分解得很差.
- 弗拉万-3-的有益健康影响很可能是由于它们对肠道微生物群的调节和与肠道上皮的相互作用,而不是代谢物形成.
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