中国湖南省耐药结核病的决定因素:一个病例控制研究
Temesgen Yihunie Akalu1,2,3, Archie C A Clements4,5, Zuhui Xu6
1School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia. t.akalu@postgrad.curtin.edu.au.
BMC infectious diseases
|February 13, 2024
概括
药物耐药结核病 (DR-TB) 在湖南省不成比例地影响少数民族,有生产年龄的人以及有先前治疗史的个人. 针对这些高风险群体的有针对性的干预措施对于控制DR-TB至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 耐药结核病 (DR-TB) 在中国湖南省构成了重大且日益严重的公共卫生挑战.
- 识别与DR-TB相关的因素对于有效的控制策略至关重要.
研究的目的:
- 确定与湖南省耐药结核病 (DR-TB) 相关的社会人口和临床因素.
- 为预防和控制DR-TB提供有针对性的公共卫生干预信息.
主要方法:
- 在2013年至2018年期间,湖南省进行了一项病例控制研究.
- 通过培养和药物敏感性测试 (DST) 确定了DR-TB病例和药物敏感性结核病 (DS-TB) 对照.
- 使用多变量逻辑回归分析来确定DR-TB的重大风险因素.
主要成果:
- 这项研究包括17808名患者 (2274例DR-TB病例,15534例DS-TB对照).
- 与耐药结核病显著相关的因素包括年龄在15-64岁之间,属于少数民族,以及以前接受过结核病治疗的病史.
- 在湖南省以外居住也被确定为DR-TB的重要风险因素.
结论:
- 对于湖南省DR-TB预防的干预措施,应优先考虑高风险群体:少数民族,有生产力年龄的个人以及以前接受过结核病治疗的人.
- 还建议针对居住在省外的个人.
- 了解省级风险因素对于定制控制策略至关重要,这些控制策略应考虑到社会经济和医疗保健准入差异.
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