贫困生活和加速生物衰老:来自美国成年人人口代表性样本的证据
Andrea Dalecka1, Anna Bartoskova Polcrova1, Hynek Pikhart1,2
1RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
BMC public health
|February 13, 2024
概括
社会经济劣势,特别是较高的贫困水平,与加速的生物衰老有关. 这种效应在中年成年人中最为明显,增加了他们早期健康问题的风险.
科学领域:
- 老年学与公共卫生
- 衰老的生物标志物
- 健康的社会经济决定因素
背景情况:
- 生物衰老,即身体功能下降,与时间年龄有关,可以加快.
- 加快的生物衰老 (生物衰老加速) 意味着早发病和死亡的风险增加.
- 社会经济因素,特别是贫困,越来越多地被认为对健康轨迹产生重大影响.
研究的目的:
- 调查社会经济劣势,特别是贫困与生物衰老加速之间的关联.
- 为了确定贫困是否影响美国成年人口代表生物衰老的速度.
- 确定受贫困相关生物衰老影响最严重的特定年龄组.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) IV (1999-2018) 的数据,其中N = 48,348人.
- 估计使用11个生物标志物的生物年龄加速,以PhenoAge加速 (PAA) 和Klemera-Doubal生物年龄加速 (KDM-A) 进行索引.
- 对贫困水平 (5类),年龄,教育,性别,种族和调查波的回归PAA和KDM-A,考虑样本权重.
主要成果:
- 较高的贫困水平与加速的生物衰老有显著的关联 (PAA:B = 1.38,p <.001;KDM-A:B = 0.96,p = .026).
- 生物衰老加速和年龄之间的关系呈现出U形图案.
- 贫困和年龄之间的显著相互作用 (p <.001) 表明贫困对衰老的影响在中年成人中最为明显.
结论:
- 较高的贫困是美国成年人口加速生物衰老的重要预测因素.
- 贫困对生物衰老的影响在中年人群中尤为明显.
- 研究结果强调了社会经济地位在健康差异和衰老过程中的关键作用.
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