稳定状态支气管切除症中高灵敏度C反应蛋白水平预测了恶化的风险
Wang Chun Kwok1, Kay Cheong Teo1, Kui Kai Lau1
1Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China.
BMC pulmonary medicine
|February 13, 2024
概括
在稳定状态下,高灵敏度C反应蛋白 (hs-CRP) 预测支气管切开症恶化. 升高的hs-CRP表明慢性炎症和支气管切除症患者未来严重事件的风险增加.
科学领域:
- 肺部医学 肺部医学
- 炎症研究 炎症研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 系统性炎症标志物与支气管切除症的严重程度,肺功能减弱和恶化风险相关.
- 高灵敏度C-反应蛋白 (hs-CRP) 显示,在稳定非囊性纤维化 (CF) 支气管支瘤中,与HRCT得分和氧气和有联系.
- 关于hs-CRP在支气管病变预后和恶化预测中的作用的数据有限.
研究的目的:
- 为了研究血清hs-CRP基线水平在稳定的患者队列中对支气管切除症恶化的预测价值.
- 探索hs-CRP与任何支气管病变加剧和住院支气管病变加剧的风险之间的关联.
主要方法:
- 在2021年10月至12月期间,对123名非CF支气管支气管病的中国患者进行了前性研究.
- 基线血清hs-CRP水平是在疾病稳定状态期间测量.
- 患者被跟踪了一年,以记录任何支气管炎症恶化和住院支气管炎症恶化的发生率.
主要成果:
- 较高的hs-CRP基线水平显著与患上任何支气管切除症恶化的风险增加有关 (aOR = 2.254,p = 0.039).
- 在较高的hs-CRP和住院支气管切除症恶化的风险增加之间观察到一个边界显著的关联 (aOR = 1.985,p = 0.080).
结论:
- 稳定支气管切除症患者的血清hs-CRP基线水平可以预测未来恶化的风险.
- hs-CRP反映了支气管炎症的潜在慢性低度炎症,作为潜在的预后标志物.
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