通过液体分布和体积功率输入来验证在中等粘度的震动瓶实验中的计算流体动力学
Carl Dinter1, Andreas Gumprecht2, Matthias Alexander Menze1
1RWTH Aachen University, Forckenbeckstraße 51, 52074, Aachen, Germany.
Scientific reports
|February 13, 2024
概括
计算流体动力学 (CFD) 建模准确地预测了各种条件下的摇瓶中的液体分布. 这种经过验证的CFD方法通过计算输入功率来帮助生物工艺设计和扩展.
科学领域:
- 生物技术是生物技术.
- 化学工程是化学工程的重要组成部分.
- 流体动力学 流体动力学
背景情况:
- 计算流体动力学 (CFD) 对于生物工艺设计和扩展至关重要.
- 在震动瓶中CFD应用的探索比在式反应器 (STR) 较少,特别是对于非类似水的粘度.
- 模型验证对于生物处理中准确的CFD模拟至关重要.
研究的目的:
- 建立和验证一个 OpenFOAM CFD 模型,用于震动瓶.
- 评估模型预测液体分布和体积输入功率的能力.
- 为生物工艺开发提供可靠的CFD工具,涉及震动瓶.
主要方法:
- 开发了一个OpenFOAM CFD模型,用于振动瓶模拟.
- 将CFD计算的液体分布与各种摇动条件和粘度 (高达16.7mPa·s) 的实验数据进行比较.
- 基于从CFD模拟中得出的能量消耗计算的体积输入功率.
主要成果:
- 差价合约模型表现出与实验数据对液体分配形状和位置的良好一致.
- 计算的体积输入功率在0.1到7kW/m3之间.
- 计算和测量的体积输入功率之间的平均差异仅为0.01 kW/m3.
结论:
- 经过验证的CFD模型准确地预测了摇瓶中的液体分布.
- 该模型提供可靠的体积输入功率估计,这对于生物工艺扩展至关重要.
- 这种CFD方法增强了基于摇瓶的生物工艺的设计和优化.
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