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含有克林达米辛的富血小板纤维素 (PRF) 的抗菌作用

Anton Straub¹, Maximilian Stapf², Chiara Utz³

¹Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany. Straub_A@ukw.de.

Clinical oral investigations

|February 14, 2024

概括

富含血小板纤维素 (PRF) 有效地携带克林达米辛 (CLI),证明其适合作为生物载体. 这一发现支持PRF.

科学领域:

生物材料科学生物材料科学
传染性疾病传染性疾病
口腔和牙面部外科手术

背景情况:

富含血小板纤维素 (PRF) 已经显示出作为抗生素的载体的潜力,如安培/硫巴克坦.
克林达米辛 (CLI) 是一种常用于治疗各种感染的抗生素.

研究的目的:

评估PRF是否可以作为克林达米辛 (CLI) 的合适生物载体.
为了评估在PRF膜内的克林达米的度和抗菌疗效.

主要方法:

从36名静脉注射克林达米辛的患者中制备了PRF膜.
在PRF中用液体染色学-并联质谱法量化了克林达米辛度.
在体外抗菌活性被测试对相关细菌使用阿加扩散试验.

主要成果:

在PRF膜中,克林达米的平均度为0.7±0.4μg/100mgPRF.
观察到抗菌活性是针对黄金葡萄球菌,肺炎性链球菌,杆菌, Porphyromonas gingivalis 和 Fusobacterium nucleatum.
抑制区表明新鲜和24小时存储的PRF具有有效的抗菌作用.

结论:

富含血小板的纤维素是适合系统注射克林达米辛的生物载体.
在PRF中克林达胺的度足以向临床相关的细菌.
在口腔和面外科手术中,PRF有可能在局部抗生素输送中扩大应用,以预防口腔和面外科手术中的感染.

关键词:

阿加尔扩散试验抗生素抗生素是一种抗生素.感染感染感染骨骨是一种骨.本地应用程序本地应用程序在 PRF 的情况下,PRF 是 PRF.

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