新的黄素装载纳米囊作为一种治疗替代品在一个记忆丧失模型
Karline da Costa Rodrigues1, Manoel Rodrigues da Silva Neto2, Victor Dos Santos Barboza3
1Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), Pelotas, RS, CEP 96010-900, Brazil.
Metabolic brain disease
|February 14, 2024
概括
黄素纳米囊有效地逆转了小鼠的记忆丧失和抑郁行为. 纳米粒子配方显示出长时间的作用,这表明神经系统疾病的治疗潜力增强.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 黄素 (Cur) 具有治疗潜力,但其生物可用性较差.
- 纳米囊 (Nc) 配方可以提高药物输送和疗效.
- 斯科波胺 (SCO) 是一种在动物模型中诱导失忆症和相关并发症的标准剂.
研究的目的:
- 为了评估使用尤德拉吉特 (EUD) 和聚 (ɛ-caprolactone) (PCL) 的氨酸纳米囊 (Cur Nc) 针对氨酸诱导的失忆症和并发症.
- 评估Cur Nc对胆固醇系统,氧化应激和炎症的影响.
- 为了比较Cur Nc与自由黄素 (Cur) 的疗效,并研究治疗频率的影响.
主要方法:
- 给瑞士小鼠注射了含有黄素的纳米囊 (Cur EUD Nc,Cur PCL Nc) 和免费的Cur.
- 斯科波胺 (SCO) 用于诱导失忆症,抑郁症和焦虑症等行为.
- 行为测试 (巴恩斯迷宫,开放场地等) 并进行生物化学测试 (AChE,CAT,TBARS,炎症标志物).
主要成果:
- 黄素治疗 (无论是Nc还是免费) 显著地保护了SCO诱导的失忆症和类似抑郁的行为.
- 库尔Nc和自由库尔降低了乙胆酶 (AChE) 活性,氧化应激标志物 (TBARS,RS,NSPH) 和炎症细胞因子 (IL-6,TNF).
- 与自由Cur相比,交替日服用的Cur Nc显示出更明显的抗丧作用,表明其作用延长了.
结论:
- 黄素纳米囊在改善小鼠中斯科波拉胺诱导的认知缺陷和情绪障碍方面是有效的.
- 纳米载体系统可以增强黄素的治疗效果,并有可能减少剂量的频率.
- 这项研究强调了黄素纳米囊作为治疗神经疾病的治疗策略的潜力,包括记忆障碍和情绪障碍.
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