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Updated: Jul 3, 2025

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

Published on: October 18, 2022

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强大的微型基于Cas的转录调制通过工程Un1Cas12f1和连接Sso7d

Xiangnan Wang1, Lingyun Li1, Li Guo2

  • 1Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 14, 2024
PubMed
概括

研究人员开发了miniCRa和miniCRi,小型的CRISPR-Cas12f系统用于基因激活和沉默. 这些系统包装在腺相关病毒 (AAV) 载体中,显示出用于基因治疗应用的高效率.

关键词:
在 AAV AAV AAV 中.这是一个小小的小事.这就是Sso7d.在Un1Cas12f1-3RR中使用.miniCRa/i 的使用情况.这是一个微型的CRISPR.转录激活的转录激活转录的压制转录的压制

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