相关实验视频

Updated: Jul 3, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

前列腺癌治疗后的二次膀和结直肠癌:一个基于人口的研究研究

Patricia Grisel Quintana Bárcena^1,2, Armen Garo Aprikian^1,3, Alice Dragomir^1,2,4

¹Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada.

Cancer medicine

|February 14, 2024

概括

前列腺癌治疗方法,如外部束辐射疗法 (EBRT) 和雄激素剥夺疗法 (ADT),与二次膀和结直肠癌的风险增加有关. 在这项研究中,支臂疗法 (BT) 也显示出与结直肠癌的相关性.

科学领域:

在瘤学瘤学.
癌症流行病学癌症流行病学
辐射瘤学辐射瘤学

背景情况:

接受放射治疗的前列腺癌 (PCa) 患者可能面临患二次恶性瘤的风险增加.
了解各种PCa治疗对二次癌症风险的长期影响对于患者护理至关重要.

研究的目的:

研究不同前列腺癌 (PCa) 治疗方法与二次膀和结直肠癌的发病率之间的关联.
为了比较与急性前列腺切除术 (RP) 相关的二次恶性瘤的风险,外部束辐射疗法 (EBRT),支架疗法 (BT) 和雄激素剥夺疗法 (ADT).

主要方法:

一项队列研究利用北克行政数据库 (Med-Echo,RAMQ) 对2000年至2016年期间诊断和治疗的PCa患者进行了研究.
以前患有膀或结直肠癌的患者被排除在外. 随访持续到二次癌症诊断,死亡或2016年底.
治疗权重的反向概率 (IPTW) 和考克斯比例危险模型被用于控制混因素.

主要成果:

外部光束辐射疗法 (EBRT) 和带有雄激素剥夺疗法 (ADT) 的EBRT与增加二次膀癌风险显著相关.
二次结直肠癌与EBRT,支臂治疗 (BT) 和ADT有显著的关联.
单独使用抗雄激素剥夺疗法 (ADT) 显着与二次膀和结直肠癌的风险增加有关.

结论:

与RP相比,包括EBRT和ADT (单独或联合) 在内的前列腺癌治疗与二次膀癌的风险增加有关.
EBRT,BT和ADT都与二次结直肠癌的发病率较高有关.
这些发现强调了在选择前列腺癌治疗方法时考虑二次癌症风险的重要性.

关键词:

雄激素剥夺疗法是一种治疗方法.膀癌:膀癌是一种癌症.支臂疗法 (brachytherapy) 是一种治疗方法.结肠直肠癌是什么意思外部光束辐射治疗.前列腺癌是前列腺癌.二次性恶性瘤的发生.

更多相关视频

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

相关概念视频

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....