慢性咳:结束已经近了吗?
Barnaby Hirons1,2, Richard Turner3,4, Peter S P Cho1,2
1Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, King's College London, London, UK.
Breathe (Sheffield, England)
|February 14, 2024
概括
难治性或无法解释的慢性咳 (RU-CC) 可能源于咳过敏. 新兴的治疗方法,包括神经调节剂和新型药物,如 gefapixant,提供希望,尽管研究缺口仍然存在.
科学领域:
- 肺部病理学 肺部病理学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性咳,定义为持续超过8周,显著影响患者的心理社会福祉.
- 耐火性或不明原因慢性咳 (RU-CC) 仍然是一个挑战,尽管制定了指导方针.
- 越来越多的证据表明,在RU-CC.中,咳过敏,得到神经病理学发现的支持.
研究的目的:
- 审查当前对慢性咳的理解,重点关注咳过敏.
- 讨论RU-CC的诊断和治疗方法的进展.
- 突出慢性咳管理领域的未来方向和挑战.
主要方法:
- 关于慢性咳的最新科学见解和临床证据的审查.
- 讨论神经病理学证据,包括吸入性咳挑战测试,fMRI和神经活检.
- 对当前和新兴的药物 (神经调节剂,P2X3抗剂) 和非药物治疗方法的分析.
主要成果:
- 咳过敏越来越被认为是RU-CC的关键机制.
- 新的治疗策略正在出现,包括P2X3受体对抗剂fefapixant.
- 重用的神经调节剂药物在治疗慢性咳方面表现有前途.
结论:
- 虽然需要更好的数据和临床试验等挑战仍然存在,但慢性咳治疗的前景正在改善.
- 对诊断工具,流行病学数据和机制研究的进一步研究至关重要.
- 针对性治疗和改进的管理策略的开发为慢性咳患者提供了乐观的希望.
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