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骨髓系衍生抑制细胞在慢性血病中的作用

Shuiping Hou1,2, Fandong Kong3, Xintong Li4

  • 1Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.

Frontiers in cellular and infection microbiology
|February 14, 2024
PubMed
概括

骨髓原抑制细胞 (MDSCs) 在慢性血病患者中增加,抑制T细胞功能. 这一发现提供了对持续性布鲁塞拉感染和潜在治疗方法的见解.

关键词:
阿尔金纳-1 的作用.在MDSCs中.这种疾病的发病地址是:brucellosis.慢性感染 慢性感染免疫抑制是一种免疫抑制.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...