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布罗利祖马布诱导的单独上皮质激素 (ACTH) 缺乏症

Khalid Alfares^1,2, Hye Jeong Han³

¹Endocrinology, Diabetes and Metabolism, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.

|February 14, 2024

概括

布罗利祖马布免疫疗法可能导致罕见但严重的二次上腺功能不全. 早期诊断和皮质类固醇治疗对于治疗癌症患者这种罕见的副作用至关重要.

科学领域:

免疫治疗是一种免疫疗法.
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

布罗利祖马布是一种被编程死亡1受体 (PD-1) 抑制剂,用于癌症免疫治疗.
它被批准用于转移性黑色素瘤,非小细胞肺癌和高风险的三阴性乳腺癌.

研究的目的:

报告布罗利祖马布诱导的隔离二次上腺功能不全 (AI) 的病例.
为了强调识别和管理这种罕见并发症的重要性.
强调需要在接受 pembrolizumab.com 治疗的患者中对上腺功能进行警监测.

主要方法:

一个44岁的女性病例报告,有三阴性乳腺癌病史.
在 pembrolizumab 治疗后,患者表现出疲劳和口服摄入不足.
二次性AI的诊断得到证实,并开始使用皮质类固醇治疗.

主要成果:

患者被诊断为隔离的二次上腺功能不全.
皮质类固醇治疗导致症状改善.
最初的血清皮质醇水平极低,需要重复测试.

结论:

布罗利祖马布诱导的二次人工智能是一种罕见但可能危及生命的并发症.
及时诊断和使用皮质类固醇的治疗对于有利的结果至关重要.
考虑对边界低水平的患者进行连续皮质醇测试,以优化管理.

关键词:

这种行为缺陷缺乏.上腺功能不全的情况.与化疗相关的毒性与化疗有关的毒性.皮质醇水平较低的人.这是一种pd-1抑制剂.这就是Pembrolizumab.下垂体荷尔蒙的产生.

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