广泛的潜在的恶感受体过度活跃延续了切口伤害后增强的回避行为
Alexis G Bavencoffe1, Elia R Lopez1, Kayla N Johnson1
1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston.
bioRxiv : the preprint server for biology
|February 14, 2024
概括
手术后,知觉受体可能会变得过度活跃,表现出与疼痛相关的长期电活动. 这种潜伏的过度活动,即使在遥远的神经元中,也可能导致焦虑并放大疼痛敏感度.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 细胞电生理学 细胞电生理学
背景情况:
- 背部根腺 (DRG) 中的感受器可以切换到过度活跃状态,表现出持续活动 (OA).
- 这种OA在脊髓损伤 (SCI) 模型中观察到,并与神经病痛有关.
- 调查OA机制需要了解它是由各种痛苦条件诱导的原因.
研究的目的:
- 为了确定 nociceptor OA 是否被术后疼痛诱导,超出神经病痛.
- 在术后疼痛模型中描述OA的电生理特性和持续时间.
- 探索广泛传播的恶感受体OA的潜在体内功能.
主要方法:
- 从患有术后疼痛 (脚部切口) 的老鼠中分离和培养DRG神经元.
- 电生理记录以评估神经元活动,包括自发波动 (DSF) 和动能 (AP) 放电.
- 行为测试来评估疼痛指标,如后腿保护和避免.
主要成果:
- 手术后的疼痛诱导了可能的恶性感受器中的OA,在AP值附近最明显.
- 潜伏性OA持续至少3周,持续时间超过行为疼痛迹象.
- 持续观察到增强的DSF;在遥远的胸部DRG神经元中也发现了OA.
结论:
- 术后疼痛可以触发nociceptor OA,这表明它在神经病变之外发挥了更广泛的作用.
- 在DRG神经元中潜伏的OA,包括远处的神经元,表明长期疼痛状态的潜在机制.
- 广泛传播的恶感受体OA可能会导致过敏性原始化和与焦虑相关的过度警.
相关概念视频
01:44Nociception
27.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.9K
01:28Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
822
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
822
01:20Pain
481
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
481
01:25Analgesia and Pain Management
623
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
623