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晚级Hypsibius exemplaris中FGF和BMP通路基因的表达模式

Kira L Heikes^1,2, Bob Goldstein^1,2,3

¹Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

bioRxiv : the preprint server for biology

|February 14, 2024

概括

这项研究绘制了骨形态遗传蛋白 (BMP) 和纤维细胞生长因子 (FGF) 在晚期胚胎发育过程中信号通路基因的表达. 这些发现提供了对后期Hypsibius exemplaris保存的发育机制的新见解.

科学领域:

发育生物学是发展生物学.
进化发育生物学进化发育生物学
动物发展动物发展

背景情况:

保存的信号通路调节动物的发育,但它们在迟级胚胎发生中的作用基本上是未知的.
迟级动物拥有独特的身体结构,使得它们的发育途径具有显著的进化兴趣.

研究的目的:

为了研究骨形态遗传蛋白 (BMP) 和纤维细胞生长因子 (FGF) 在晚期胚胎发育过程中信号通路组件的表达模式.
假设BMP和FGF信号在胚胎细分和中皮形成中的作用Hypsibius exemplaris.

主要方法:

在Hypsibius exemplaris胚胎细分和中皮发育期间检查了BMP和FGF通路组件的基因表达模式.
利用对模型生物中已知的作用进行比较分析来制定假设.

主要成果:

鉴定了FGF连接体在外皮部分后部和FGF受体在内皮囊中的表达,这表明了细菌层之间的信号传递.
观察到BMP连接体在侧侧外皮和背侧皮带中的表达,而BMP抗体Sog在侧侧外皮和内膜皮表达,表明在背腔腹腔模式中的潜在作用.

结论:

这项研究提供了BMP和FGF信号基因表达的第一个描述.
鉴定的表达模式允许制定可测试的假设,关于这些保存途径在晚期胚胎细分和中皮发育中的功能.

关键词:

在BMP中,BMP是BMP.联邦政府财政基金.半层皮质 (Mesoderm) 是一种中层皮质 (Mesoderm).分段化分段化分段化分段化这种类型的尾动物是尾动物.

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