在成年人与线粒体疾病的情绪和症状严重程度的感知关联
Catherine Kelly1, Alex Junker1, Kris Englestad2
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
medRxiv : the preprint server for health sciences
|February 14, 2024
概括
情绪可能会影响线粒体疾病的症状严重程度. 压力和负面情绪可能会加剧疲劳和脑雾等症状,而冷静可能会改善症状.
科学领域:
- 神经学 神经学
- 遗传学 遗传学 是一个
- 心理学 心理学 心理学
背景情况:
- 遗传性线粒体疾病会导致多系统症状变化.
- 线粒体疾病中每日症状波动的原因尚不清楚.
- 压力事件和心理状态与神经系统疾病和线粒体功能有关.
研究的目的:
- 为了研究一种假设,即线粒体疾病中的症状严重程度与参与者的情绪相关.
- 探索情绪状态和特定症状波动之间的关系.
主要方法:
- 向70名成年人进行了压力,健康和情绪调查 (SHES),这些成年人自我报告了线粒体疾病.
- 参与者对过去一年的"好"和"坏"天的症状严重程度进行了评分.
- 包括患有MELAS,CPEO和复合I缺乏症的人.
主要成果:
- 负面情绪 (压力,悲伤) 与疲劳的严重程度增加,运动不耐受,脑雾和精细运动协调有关.
- 积极的情绪 (快乐,平静) 与这些症状的严重程度降低有关.
- 诸如出汗减少,听力问题和心力衰竭等症状通常与情绪无关.
结论:
- 一些患有线粒体疾病的人认为他们的情绪和症状严重程度之间存在联系.
- 初步发现表明情绪是影响某些线粒体疾病症状临床过程的潜在因素.
- 对于线粒体疾病症状变化的综合模型,需要进一步的研究.
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