对慢性背痛的恢复力的大脑白质路径:一个多站点验证
Mina Mišić1, Noah Lee2, Francesca Zidda1
1Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.
bioRxiv : the preprint server for biology
|February 14, 2024
概括
大脑成像揭示了右上纵向囊 (SLF) 通道的完整性预测慢性背痛 (CBP) 的发展. 在亚急性背痛患者中,较高的SLF分数异质性 (FA) 表明了性和恢复潜力.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
背景情况:
- 慢性背痛 (CBP) 构成了全球健康的重大负担.
- 慢性CBP的预测因素是多因素的,包括心理社会和大脑特征.
- 对CBP的神经成像预测因子的大规模验证缺乏.
研究的目的:
- 为了验证大脑白质特征作为慢性背痛 (CBP) 发展的预测因素.
- 为了研究右上纵向 (SLF) 在慢性背痛中的作用.
- 评估神经成像标记物的临床可翻译性,以预测背部疼痛的结果.
主要方法:
- 在6个月和12个月的时间内对亚急性背痛 (SBP) 患者的白质扩散成像数据进行纵向分析.
- 基于通道的空间统计 (TBSS) 来分析右SLF中的分数异构 (FA).
- 恢复 (SBPr),持续疼痛 (SBPp) 患者和健康对照 (HC) 之间的扩散数据的比较.
- 使用第三个独立数据集和结构连接模型进行验证.
主要成果:
- 在康复 (SBPr) 的患者中,与持久疼痛 (SBPp) 患者相比,在右上纵向囊 (SLF) 中观察到较高的分数异位性 (FA).
- 正确的SLF FA值预测了疼痛严重程度的变化,并在数据集 (AUC ~ 0.70) 中准确地分类了患者.
- 康复的患者显示SLF FA比健康对照人高,这表明它在抵御慢性背痛方面发挥了作用.
结论:
- 右上纵长 (SLF) 被证实是慢性背痛 (CBP) 发展的强有力的预测因素.
- SLF的完整性可能在抵抗慢性背痛时起到至关重要的作用.
- 在早期针对依赖于正确的SLF (例如,自身感知,视觉空间注意力) 的认知和行为过程,可能有助于预防CBP慢性.
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