任务激活导致人类大脑中区域C-乳酸盐信号的增加
bioRxiv : the preprint server for biology
|February 14, 2024
概括
超极化13CMRI检测到视觉任务期间在激活的大脑区域增加13C-乳酸盐. 这种成像技术成功地测量了大脑的代谢变化,突出了乳酸生产.
科学领域:
- 神经成像是一种神经成像.
- 代谢成像成像 - 代谢成像
- 生物化学 生物化学
背景情况:
- 超极化13CMRI (HP-13C MRI) 提供了一种非侵入性方法来研究大脑新陈代谢.
- 了解功能激活期间的大脑代谢变化对于神经科学研究至关重要.
研究的目的:
- 使用HP-13CMRI,在视觉刺激期间研究大脑中13C-乳酸盐,13C-酸盐和13C-二碳酸盐产生的变化.
- 为了比较视觉刺激条件和闭眼对照条件之间的代谢活动.
主要方法:
- 健康的志愿者 (N=6) 接受了两次HP-13C核磁共振扫描,并注射了超极化13C-pyruvate.
- 使用BOLD-fMRI识别了功能激活的大脑区域.
- 将13C代谢物信号正常化为脑干信号,并计算条件之间的百分比变化.
主要成果:
- 与大脑其余部分相比,在激活的大脑区域观察到13C-乳酸盐信号的显著增加 (p=0.02).
- 在13C-酸盐 (p=0.11) 或13C-二碳酸盐 (p=0.95) 信号中没有发现显著变化.
- 这些发现表明,大脑代谢活跃区域的乳酸盐产量增加.
结论:
- HP-13CMRI可以有效地测量在代谢活跃的大脑区域中增加的13C-乳酸盐产量.
- 这项研究证明了HP-13CMRI在可视化大脑功能代谢反应方面的实用性.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Feedback Regulation of Calcium Concentration
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Calmodulin-dependent Signaling
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...


