在老鼠和人类中,thalamic反会塑造皮质刺激引起的大脑反应
Simone Russo1,2,3,4, Leslie Claar3, Lydia Marks3
1Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan 20157, Italy.
bioRxiv : the preprint server for biology
|February 14, 2024
概括
皮层刺激会触发大脑深层电路,在人类和小鼠中产生类似的唤起潜能 (EP). 一个受行为影响的体反弹机制驱动这些反应,揭示了保存的神经通路.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 单脉冲皮质刺激被广泛使用,但其对皮质下回路的参与仍然不清楚.
- 皮质下电路在皮质刺激后对唤起的潜能 (EP) 起着显著的作用.
研究的目的:
- 调查皮层刺激所涉及的皮层下电路及其对EPs的贡献.
- 阐明皮层刺激唤起潜力的晚期组件背后的机制.
- 为了比较跨物种的EP生成,并探索行为调制.
主要方法:
- 在皮层刺激后,对人类和小鼠的唤起潜能 (EP) 的比较分析.
- 在小鼠中神经回路的光遗传剖析,以确定晚期EP组件的来源.
- 在体内电生理学记录thalamic神经元活动和爆发.
- 电脑模拟的thalamo-皮质电路.
主要成果:
- 皮层刺激在人类和小鼠中引起了非常相似的EP,包括晚期组件.
- 晚期EP组件在小鼠中是由于thalamic超极化和反弹,由行为状态调节.
- thalamic神经元爆发频率和同步性与晚期EP组件的大小相关.
- 模拟表明,在皮层和胸膜区域内,内在的胸膜电流和GABAergic神经元的贡献.
结论:
- 皮质刺激涉及皮质-甲状腺-皮质电路,这些电路在物种之间高度保存.
- thalamic机制,包括反弹活动,对于产生迟唤起的潜能至关重要.
- 行为状态显著调节这些保留的皮层-脑丘脑反应.
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