在生命的前两年,大脑与行为关系的性别差异
Sonja J Fenske1,2, Janelle Liu1,2, Haitao Chen1,2,3
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
bioRxiv : the preprint server for biology
|February 14, 2024
概括
大脑连接的性别差异在婴儿期出现,将神经模式与以后的认知和行为结果联系起来. 这些大脑行为关系在早期发育过程中在男性和女性之间是不同的.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 儿童认知中确定的性别差异缺乏明确的神经支.
- 婴儿大脑行为关系显示异质性,但基于性别的影响仍然不清楚.
研究的目的:
- 调查婴儿时期神经机制的基于性别的差异.
- 检查性如何影响从新生儿到2岁的大脑行为关系.
- 识别与以后的行为发展相关的性别特定的大脑连接模式.
主要方法:
- 利用休息状态功能磁共振成像 (fMRI) 对316名3周,1岁和2岁的婴儿.
- 采用多重线性回归来分析性别和功能连接之间的相互作用.
- 在4岁时评估工作记忆,抑制自我控制,智力和焦虑的行为评分.
主要成果:
- 确定了六个特定于年龄的半球内连接,在功能连接性-行为关系中存在显著的性别差异.
- 这些连接涉及前额叶皮层或极,对认知功能至关重要.
- 性别之间的连接性差异依赖于行为,不单独存在,在男性和女性中观察到不同的模式.
结论:
- 建立了强大的,与发展过程中的行为结果相关的性别特异性大脑机制.
- 大脑与行为之间的关系是理解早期发育中的性别差异的关键因素.
- 研究结果强调了在发育神经科学研究中考虑性别的重要性.
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