在阿尔茨海默病和轻度认知障碍中,明显的牙皮层网络中的功能连接差异
Ivan A Herrejon1, T Bryan Jackson1,2, Tracey H Hicks1
1Department of Psychological and Brain Sciences Texas A&M University.
bioRxiv : the preprint server for biology
|February 14, 2024
概括
小脑是小脑的组成部分.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 最近的研究表明小脑与阿尔茨海默病 (AD) 有关.
- 大脑小脑网络连接是AD症状严重性的潜在因素.
- 小脑牙状核 (DN) 有明显的运动和非运动子区域,与大脑皮层平行投射.
研究的目的:
- 在轻度认知障碍 (MCI) 和AD患者与认知正常 (CN) 个体相比,研究背部 (dDN) 和腹部 (vDN) DN网络的功能连接 (FC) 差异.
- 检查DN网络FC与MCI和AD的行为症状之间的关系.
- 在临床诊断之前了解小脑对AD病理学的贡献.
主要方法:
- 背部和腹部牙状核 (DN) 网络的功能连接性 (FC) 分析.
- 在阿尔茨海默病 (AD),轻度认知障碍 (MCI) 和认知正常 (CN) 参与者中对FC模式的比较.
- DN网络FC与运动和认知行为措施之间的相关性分析.
主要成果:
- 与认知正常 (CN) 个体相比,阿尔茨海默病 (AD) 患者在背部 (dDN) 和腹部 (vDN) 牙核 (DN) 网络中表现出功能连接 (FC) 的增加和减少.
- 与MCI患者相比,AD患者的连接性较低,这表明在AD中更高的FC具有潜在的补偿作用.
- 在dDN连接和运动症状之间,以及在dDN和vDN连接和认知任务表现之间,发现了显著的关联.
结论:
- 大脑牙核 (DN) 网络在阿尔茨海默病 (AD) 中受到影响,影响行为.
- 在DN网络中改变的功能连接 (FC) 可能代表AD中的补偿机制.
- 这些发现突出了小脑在认知功能和衰老中的关键作用,为未来的AD诊断和理解提供了信息.
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