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Updated: Jul 3, 2025

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从T细胞谱中学习HLA类型的预测特征

Maria Ruiz Ortega, Mikhail V Pogorelyy, Anastasia A Minervina

    bioRxiv : the preprint server for biology
    |February 14, 2024
    PubMed
    概括

    研究人员将T细胞受体 (TCR) 与人类白细胞抗原 (HLA) 的等位基因联系起来,从而能够从TCR谱中预测HLA类型. 这一进步有助于理解免疫反应和预测TCR抗原特异性.

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    T Cell Activation and Clonal Selection01:22

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    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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