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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Updated: Jul 3, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

全球MEG休息状态自闭症和感官处理功能障碍儿童的功能连接

Carly Demopoulos^1,2, Xuan Jesson³, Molly Rae Gerdes⁴

¹Department of Psychiatry, University of California San Francisco, 675 18 Street, San Francisco, CA 94107.

bioRxiv : the preprint server for biology

|February 14, 2024

概括

患有自闭症谱系障碍 (ASD) 和感官处理功能障碍 (SPD) 的儿童表现出不同的大脑连接模式. 这些神经同步差异可能有助于确定这两种疾病的生物标志物.

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科学领域:

神经科学是一个神经科学.
发育神经科学的发展神经科学.

背景情况:

感官处理功能障碍 (SPD) 影响自闭症谱系障碍 (ASD) 患者和其他没有ASD的人.
感官功能障碍和静止状态大脑活动之间的联系尚未得到充分理解.

研究的目的:

为了比较ASD儿童,SPD儿童 (没有ASD) 和典型发育儿童 (TDC) 的长距离静止状态功能连接.
为了研究在α和β频段内神经振荡行为的差异.
检查感官处理能力和功能连接模式之间的关联.

主要方法:

磁脑电图 (MEG) 用于记录8-12岁儿童的静止状态大脑活动.
功能连接分析在α (8-12 Hz) 和β (13-30 Hz) 频段进行.
进行了群体 (ASD,SPD,TDC) 之间的统计比较,并评估了连接性和感官功能之间的相关性.

主要成果:

在ASD和SPD组之间,仅在β频段中观察到明显的功能连接差异.
与TDC组相比,ASD和SPD组在阿尔法和β频段都表现出功能连接的改变.
体感皮层的β频带连接与触觉处理相关,听觉皮层的α频带连接与听觉处理相关.

结论:

结果揭示了SPD和ASD中明显的长距离神经同步改变.
神经同步测量显示出ASD和SPD敏感生物标志物的潜力.