用于经磁刺激的坐标系统有多准确?
Maria Anabel Uehara1, Natasha Jacobson2, Zahra Moussavi1,3
1Department of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada.
Frontiers in human neuroscience
|February 14, 2024
概括
塔拉拉赫坐标系,通常用于跨磁刺激 (TMS),可能不准确地准主运动皮层的手部区域. 这项研究发现了显著的偏差,表明一般化坐标可以误导精确的大脑刺激.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 医疗成像医学成像
背景情况:
- 神经导航系统通过个人MRI扫描来提高跨磁刺激 (TMS) 的精度.
- 塔莱拉奇坐标系在TMS中经常被用于针对特定的大脑区域.
研究的目的:
- 为了评估TMS的平均Talairach坐标在定位主要运动皮层的手部区域的准确性.
- 评估 Talairach 坐标系在引起运动反应方面的有效性.
主要方法:
- 使用来自50名健康个体的Talairach坐标,对六名参与者的MRI进行了调整,将TMS单次脉冲应用于手部区域.
- 手部肌肉的电肌图 (EMG) (abductor pollicis brevis,第一个脊椎骨干) 在静止运动值时记录了反应.
- 试错刺激在没有反应的参与者中确定了真正的手部区域.
主要成果:
- 六名参与者中有三名表现出非自愿的抽;另外三名没有表现出一致的运动反应.
- 随后的有针对性的刺激成功地定位了不响应的参与者的手部区域.
- 实际手部面积和平均塔莱拉奇坐标之间的偏差在头骨表面达到了19.5毫米.
结论:
- 一般化的Talairach坐标可能无法准确地确定TMS的主要运动皮质手部区域.
- 显著的空间差异凸显了依赖大脑刺激准的平均坐标时的潜在不准确性.
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