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工程cGAS-agonistic寡核酸作为癌症免疫疗法的治疗药物

Shurong Zhou1,2, Ting Su2, Furong Cheng2

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Molecular therapy. Nucleic acids
|February 14, 2024
PubMed
概括

我们开发了Svg3,一种新的cGAS激动剂,用于癌症免疫治疗. 这种寡核酸激活了cGAS-STING通路,增强了抗瘤免疫反应,并增强了免疫治疗的疗效.

关键词:
MT:新型治疗点和生物标志物开发 特别版cGAS 是一个气体.癌症疫苗 癌症疫苗组合免疫疗法组合免疫疗法免疫刺激剂 免疫刺激剂聚核酸的治疗药物.

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